Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/102133
Title: Effect of particle concentration on the microstructural and macromechanical properties of biocompatible magnetic hydrogels
Authors: Bonhome-Espinosa, A. B.
Campos, F.
Rodriguez, I. A.
Carriel, V.
Marins, J. A.
Zubarev, A.
Duran, J. D. G.
Lopez-Lopez, M. T.
Issue Date: 2017
Publisher: Royal Society of Chemistry
Citation: Effect of particle concentration on the microstructural and macromechanical properties of biocompatible magnetic hydrogels / A. B. Bonhome-Espinosa, F. Campos, I. A. Rodriguez, et al. — DOI 10.1039/c7sm00388a // Soft Matter. — 2017. — Vol. 13. — Iss. 16. — P. 2928-2941.
Abstract: We analyze the effect of nanoparticle concentration on the physical properties of magnetic hydrogels consisting of polymer networks of the human fibrin biopolymer with embedded magnetic particles, swollen by a water-based solution. We prepared these magnetic hydrogels by polymerization of mixtures consisting mainly of human plasma and magnetic nanoparticles with OH- functionalization. Microscopic observations revealed that magnetic hydrogels presented some cluster-like knots that were connected by several fibrin threads. By contrast, nonmagnetic hydrogels presented a homogeneous net-like structure with only individual connections between pairs of fibers. The rheological analysis demonstrated that the rigidity modulus, as well as the viscoelastic moduli, increased quadratically with nanoparticle content following a square-like function. Furthermore, we found that time for gel point was shorter in the presence of magnetic nanoparticles. Thus, we can conclude that nanoparticles favor the cross-linking process, serving as nucleation sites for the attachment of the fibrin polymer. Attraction between the positive groups of the fibrinogen, from which the fibrin is polymerized, and the negative OH- groups of the magnetic particle surface qualitatively justifies the positive role of the nanoparticles in the enhancement of the mechanical properties of the magnetic hydrogels. Indeed, we developed a theoretical model that semiquantitatively explains the experimental results by assuming the indirect attraction of the fibrinogen through the attached nanoparticles. Due to this attraction the monomers condense into nuclei of the dense phase and by the end of the polymerization process the nuclei (knots) of the dense phase cross-link the fibrin threads, which enhances their mechanical properties. This journal is © The Royal Society of Chemistry 2017.
Keywords: BIOCOMPATIBILITY
CROSSLINKING
HYDROGELS
MECHANICAL PROPERTIES
NANOMAGNETICS
NANOPARTICLES
PLASMA POLYMERIZATION
CROSS-LINKING PROCESS
MAGNETIC NANO-PARTICLES
MICROSCOPIC OBSERVATIONS
NANOPARTICLE CONCENTRATIONS
PARTICLE CONCENTRATIONS
POLYMERIZATION PROCESS
RHEOLOGICAL ANALYSIS
WATER-BASED SOLUTIONS
MAGNETOPLASMA
BIOMATERIAL
NANOPARTICLE
CHEMISTRY
FLOW KINETICS
HUMAN
HYDROGEL
MAGNET
MECHANICAL STRESS
MECHANICS
SHEAR STRENGTH
BIOCOMPATIBLE MATERIALS
HUMANS
HYDROGELS
MAGNETS
MECHANICAL PHENOMENA
NANOPARTICLES
RHEOLOGY
SHEAR STRENGTH
STRESS, MECHANICAL
URI: http://hdl.handle.net/10995/102133
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85018473660
PURE ID: 1809432
79800f44-1f00-4009-b1db-0e849bd7b425
ISSN: 1744683X
DOI: 10.1039/c7sm00388a
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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