Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101955
Title: Rheology of magnetic alginate hydrogels
Authors: Gila-Vilchez, C.
Bonhome-Espinosa, A. B.
Kuzhir, P.
Zubarev, A.
Duran, J. D. G.
Lopez-Lopez, M. T.
Issue Date: 2018
Publisher: Society of Rheology
Citation: Rheology of magnetic alginate hydrogels / C. Gila-Vilchez, A. B. Bonhome-Espinosa, P. Kuzhir, et al. — DOI 10.1122/1.5028137 // Journal of Rheology. — 2018. — Vol. 62. — Iss. 5. — P. 1083-1096.
Abstract: Magnetic hydrogels are becoming increasingly in demand for technical and biomedical applications, especially for tissue engineering purposes. Among them, alginate-based magnetic hydrogels emerge as one of the preferred formulations, due to the abundance, low cost, and biocompatibility of alginate polymers. However, their relatively slow gelation kinetics provokes strong particle settling, resulting in nonhomogeneous magnetic hydrogels. Here, we study magnetic hydrogels prepared by a novel two-step protocol that allows obtaining macroscopically homogeneous systems, consisting of magnetic microparticles embedded within the alginate network. We describe a comprehensive characterization (morphology, microstructure, and mechanical properties under shear stresses) of the resulting magnetic hydrogels. We pay special attention to the effects of particle volume fraction (up to 0.33) and strength of the magnetic field on the viscoelastic properties of the magnetic hydrogels. Our results indicate that magnetic hydrogels are strongly strengthened against shear stresses as magnetic particle concentration and applied field intensity increase. Finally, we report an adaptation of the two-step protocol for the injection of the magnetic hydrogels that might be adequate for implementation in vivo. Interestingly, injected magnetic hydrogels present similar morphology and mechanical properties to noninjected hydrogels. To conclude, we report magnetic alginate hydrogels with adequate homogeneity and injectability character. These characteristics, together with the broad range of their mechanical properties, make them perfect candidates for cutting-edge technology. © 2018 The Society of Rheology.
Keywords: ALGINATE
BIOCOMPATIBILITY
EMBEDDED SYSTEMS
GELATION
HYDROGELS
MECHANICAL PROPERTIES
MEDICAL APPLICATIONS
SHEAR STRESS
TISSUE ENGINEERING
VISCOELASTICITY
BIOMEDICAL APPLICATIONS
CUTTING EDGE TECHNOLOGY
HOMOGENEOUS SYSTEM
MAGNETIC HYDROGELS
MAGNETIC MICROPARTICLES
MORPHOLOGY AND MECHANICAL PROPERTIES
PARTICLE VOLUME FRACTIONS
VISCOELASTIC PROPERTIES
MAGNETIC FIELD EFFECTS
URI: http://hdl.handle.net/10995/101955
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85050885868
PURE ID: 7763274
1121b822-5b5e-4526-9541-0cda46b02a9d
ISSN: 1486055
DOI: 10.1122/1.5028137
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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