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Название: The lack of slow force response in failing rat myocardium: role of stretch-induced modulation of Ca–TnC kinetics
Авторы: Lookin, O.
Protsenko, Y.
Дата публикации: 2019
Издатель: Springer Tokyo
Библиографическое описание: Lookin O. The lack of slow force response in failing rat myocardium: role of stretch-induced modulation of Ca–TnC kinetics / O. Lookin, Y. Protsenko. — DOI 10.1007/s12576-018-0651-3 // Journal of Physiological Sciences. — 2019. — Vol. 69. — Iss. 2. — P. 345-357.
Аннотация: The slow force response (SFR) to stretch is an important adaptive mechanism of the heart. The SFR may result in ~ 20–30% extra force but it is substantially attenuated in heart failure. We investigated the relation of SFR magnitude with Ca 2+ transient decay in healthy (CONT) and monocrotaline-treated rats with heart failure (MCT). Right ventricular trabeculae were stretched from 85 to 95% of optimal length and held stretched for 10 min at 30 °C and 1 Hz. Isometric twitches and Ca 2+ transients were collected on 2, 4, 6, 8, 10 min after stretch. The changes in peak tension and Ca 2+ transient decay characteristics during SFR were evaluated as a percentage of the value measured immediately after stretch. The amount of Ca 2+ utilized by TnC was indirectly evaluated using the methods of Ca 2+ transient “bump” and “difference curve.” The muscles of CONT rats produced positive SFR and they showed prominent functional relation between SFR magnitude and the magnitude (amplitude, integral intensity) of Ca 2+ transient “bump” and “difference curve.” The myocardium of MCT rats showed negative SFR to stretch (force decreased in time) which was not correlated well with the characteristics of Ca 2+ transient decay, evaluated by the methods of “bump” and “difference curve.” We conclude that the intracellular mechanisms of Ca 2+ balancing during stretch-induced slow adaptation of myocardial contractility are disrupted in failing rat myocardium. The potential significance of our findings is that the deficiency of slow force response in diseased myocardium may be diminished under augmented kinetics of Ca–TnC interaction. © 2018, The Physiological Society of Japan and Springer Japan KK, part of Springer Nature.
Ключевые слова: CA 2+ TRANSIENT
HEART FAILURE
ISOMETRIC CONTRACTION
RAT MYOCARDIUM
SLOW FORCE RESPONSE
CALCIUM
MONOCROTALINE
SODIUM
SODIUM CALCIUM EXCHANGE PROTEIN
ANIMAL
CARDIAC MUSCLE
DRUG EFFECT
FEMALE
HEART
HEART CONTRACTION
HEART FAILURE
HEART VENTRICLE
KINETICS
MALE
METABOLISM
PATHOPHYSIOLOGY
RAT
WISTAR RAT
ANIMALS
CALCIUM
FEMALE
HEART
HEART FAILURE
HEART VENTRICLES
KINETICS
MALE
MONOCROTALINE
MYOCARDIAL CONTRACTION
MYOCARDIUM
RATS
RATS, WISTAR
SODIUM
SODIUM-CALCIUM EXCHANGER
URI: http://elar.urfu.ru/handle/10995/101888
Условия доступа: info:eu-repo/semantics/openAccess
Идентификатор SCOPUS: 85058675983
Идентификатор WOS: 000458691700016
Идентификатор PURE: 4caef325-bb4c-4e5b-9563-8264432ec4f0
9074708
ISSN: 18806546
DOI: 10.1007/s12576-018-0651-3
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

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