Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101864
Title: Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex
Authors: Reddy, A. S.
Krishna, L. S.
Badavath, V. N.
Sravya, G.
Reddy, N. B.
Zyryanov, G. V.
Зырянов, Г. В.
Issue Date: 2019
Publisher: American Institute of Physics Inc.
Citation: Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex / A. S. Reddy, L. S. Krishna, V. N. Badavath, et al. — DOI 10.1063/1.5087386 // AIP Conference Proceedings. — 2019. — Vol. 2063. — 040054.
Abstract: A novel 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazonecobalt (II) complex is synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, HRMS, electronic spectral analysis and Powder-X-ray diffraction. The Co(II) complex is found to be highly efficient in inhibiting the growth of human pathogens likeS. aureusand B. megaterium with MIC value 12.0 μg/mL whose inhibition zones are almost comparable with the standard antibiotic. The synthesized complex well occupies in the active site of β- ketoacyl-acyl carrier protein synthase III enzyme (PDB: 1MZS), in consists of catalytic triad and adenine-binding site, so the designed compoundis promising for to treat bacterial infection. © 2019 Author(s).
URI: http://hdl.handle.net/10995/101864
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85060432122
PURE ID: 8870317
11def740-74dc-46a3-a8e6-ab4c7b095959
ISSN: 0094243X
ISBN: 9780735417915
DOI: 10.1063/1.5087386
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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