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|Title:||Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex|
|Authors:||Reddy, A. S.|
Krishna, L. S.
Badavath, V. N.
Reddy, N. B.
Zyryanov, G. V.
Зырянов, Г. В.
|Publisher:||American Institute of Physics Inc.|
|Citation:||Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex / A. S. Reddy, L. S. Krishna, V. N. Badavath, et al. — DOI 10.1063/1.5087386 // AIP Conference Proceedings. — 2019. — Vol. 2063. — 040054.|
|Abstract:||A novel 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazonecobalt (II) complex is synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, HRMS, electronic spectral analysis and Powder-X-ray diffraction. The Co(II) complex is found to be highly efficient in inhibiting the growth of human pathogens likeS. aureusand B. megaterium with MIC value 12.0 μg/mL whose inhibition zones are almost comparable with the standard antibiotic. The synthesized complex well occupies in the active site of β- ketoacyl-acyl carrier protein synthase III enzyme (PDB: 1MZS), in consists of catalytic triad and adenine-binding site, so the designed compoundis promising for to treat bacterial infection. © 2019 Author(s).|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
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