Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101811
Title: Zebrafish models for attention deficit hyperactivity disorder (ADHD)
Authors: Fontana, B. D.
Franscescon, F.
Rosemberg, D. B.
Norton, W. H. J.
Kalueff, A. V.
Parker, M. O.
Issue Date: 2019
Publisher: Elsevier Ltd
Citation: Zebrafish models for attention deficit hyperactivity disorder (ADHD) / B. D. Fontana, F. Franscescon, D. B. Rosemberg, et al. — DOI 10.1016/j.neubiorev.2019.02.009 // Neuroscience and Biobehavioral Reviews. — 2019. — Vol. 100. — P. 9-18.
Abstract: Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing animal models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder. © 2019 Elsevier Ltd
Keywords: ADHD
BEHAVIOR
DOPAMINE
GENETICS
NORADRENALINE
SEROTONIN
ZEBRAFISH
ANTISENSE OLIGONUCLEOTIDE
TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE
VIRUS VECTOR
ANIMAL BEHAVIOR
ANIMAL EXPERIMENT
ANIMAL MODEL
ATTENTION DEFICIT DISORDER
CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT
DISEASE MODEL
DRUG DEVELOPMENT
EXPERIMENTAL BEHAVIORAL TEST
FEMALE
GENETIC PROCEDURES
MALE
MONOAMINERGIC SYSTEM
MUTAGENESIS
NEUROSCIENCE
NONHUMAN
OPTOGENETICS
PHENOTYPE
PRIORITY JOURNAL
REVIEW
SPECIES COMPARISON
TARGETING INDUCED LOCAL LESIONS IN GENOMES METHOD
TRANSLATIONAL RESEARCH
VIRAL VECTOR MEDIATED INSERTIONAL MUTAGENESIS
ZEBRA FISH
ANIMAL
ATTENTION DEFICIT DISORDER
BRAIN
GENETICS
PATHOPHYSIOLOGY
TRANSLATIONAL RESEARCH
ZEBRA FISH
ANIMALS
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY
BEHAVIOR, ANIMAL
BRAIN
DISEASE MODELS, ANIMAL
TRANSLATIONAL MEDICAL RESEARCH
ZEBRAFISH
URI: http://hdl.handle.net/10995/101811
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85062012678
PURE ID: 9062594
3cef1139-f7a9-4ec4-8540-5bdf679eda1b
ISSN: 1497634
DOI: 10.1016/j.neubiorev.2019.02.009
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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