Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101783
Title: Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Authors: Zabegalov, K. N.
Khatsko, S. L.
Lakstygal, A. M.
Demin, K. A.
Cleal, M.
Fontana, B. D.
McBride, S. D.
Harvey, B. H.
de Abreu, M. S.
Parker, M. O.
Kalueff, A. V.
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders / K. N. Zabegalov, S. L. Khatsko, A. M. Lakstygal, et al. — DOI 10.1016/j.bbr.2019.03.044 // Behavioural Brain Research. — 2019. — Vol. 367. — P. 101-110.
Abstract: Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms. © 2019 Elsevier B.V.
Keywords: ABNORMAL REPETITIVE BEHAVIOR
ANIMAL MODELS
HUMAN BRAIN DISORDERS
STEREOTYPY
ZEBRAFISH
4 AMINOBUTYRIC ACID A RECEPTOR BETA3
DOPAMINE 3 RECEPTOR
FRAGILE X MENTAL RETARDATION PROTEIN
HAMARTIN
METHYL CPG BINDING PROTEIN 2
NEUROLIGIN
RAS PROTEIN
ABNORMAL REPETITIVE BEHAVIOR
ANIMAL BEHAVIOR
BRAIN DISEASE
BRAIN FUNCTION
CLINICAL FEATURE
COGNITIVE DEFECT
CONNECTOME
EXECUTIVE FUNCTION
FRAGILE X SYNDROME
LEARNING
MOTOR DYSFUNCTION
NONHUMAN
OBSESSIVE COMPULSIVE DISORDER
PRIORITY JOURNAL
RETT SYNDROME
REVIEW
WORKING MEMORY
ZEBRA FISH
ANIMAL
ANIMAL BEHAVIOR
DISEASE MODEL
GENETICS
HUMAN
MENTAL DISEASE
MOTOR DYSFUNCTION
PATHOPHYSIOLOGY
PHYSIOLOGY
ZEBRA FISH
ANIMALS
BEHAVIOR, ANIMAL
COGNITIVE DYSFUNCTION
DISEASE MODELS, ANIMAL
EXECUTIVE FUNCTION
HUMANS
NEURODEVELOPMENTAL DISORDERS
OBSESSIVE-COMPULSIVE DISORDER
STEREOTYPIC MOVEMENT DISORDER
ZEBRAFISH
URI: http://hdl.handle.net/10995/101783
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85063763435
PURE ID: 9304365
8912ad62-9c46-4863-8d41-da092af94916
ISSN: 1664328
DOI: 10.1016/j.bbr.2019.03.044
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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