Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101489
Title: LPDs – «Linked to penumbra» discharges or EEG correlate of excitotoxicity: A review based hypothesis
Authors: Chegodaev, D.
Pavlova, N. V.
Pavlova, P.
Lvova, O.
Issue Date: 2020
Publisher: Elsevier B.V.
Citation: LPDs – «Linked to penumbra» discharges or EEG correlate of excitotoxicity: A review based hypothesis / D. Chegodaev, N. V. Pavlova, P. Pavlova, et al. — DOI 10.1016/j.eplepsyres.2020.106429 // Epilepsy Research. — 2020. — Vol. 166. — 106429.
Abstract: Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The heterogeneity of the features derived from LPDs patterns, and the wide range of pathological conditions in which they occur, raise a question about the unifying mechanisms underlying these phenomena. This paper reassesses the current opinion surrounding LPDs which considers glutamate excitotoxicity to be the primary pathophysiological basis, and the penumbral region to be the main morphological substrate. Arguments in favour of this hypothesis are presented, with interpretations supported by evidence from recent literature involving clinical and experimental data. Presently, no single hypothesis places considerable emphasis on the pathochemical properties of LPDs, which are implicitly meaningful towards better understanding of the clinical significance of this pattern. © 2020 Elsevier B.V.
Keywords: EEG
EXCITOTOXICITY
GLUTAMATE
LPDS
MECHANISM
PENUMBRA
PERIODIC DISCHARGES
PLEDS
BRAIN BLOOD FLOW
BRAIN BLOOD VESSEL
BRAIN REGION
CORRELATIONAL STUDY
DISEASE ASSOCIATION
ELECTROENCEPHALOGRAM
EPILEPTIC DISCHARGE
EXCITOTOXICITY
FOREBRAIN
HUMAN
HYPERCALCEMIA
HYPERGLYCEMIA
HYPONATREMIA
METABOLIC DISORDER
NERVE CELL
NERVE CELL STIMULATION
NERVE POTENTIAL
OCCIPITAL CORTEX
PATHOGENESIS
PERIODICITY
PRIORITY JOURNAL
REVIEW
THALAMUS
VASODILATATION
URI: http://hdl.handle.net/10995/101489
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85088098574
PURE ID: 13384781
b098017d-91a8-4cfc-8386-e1f2e3547418
ISSN: 9201211
DOI: 10.1016/j.eplepsyres.2020.106429
metadata.dc.description.sponsorship: This work was supported by the Russian Science Foundation [grant number 16-18-10371 ].
RSCF project card: 16-18-10371
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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