Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101442
Title: Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms
Authors: Ivanova, A.
Gerasimova, E.
Gazizullina, E.
Issue Date: 2020
Publisher: MDPI AG
Citation: Ivanova A. Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms / A. Ivanova, E. Gerasimova, E. Gazizullina. — DOI 10.3390/molecules25184251 // Molecules. — 2020. — Vol. 25. — Iss. 18. — 4251.
Abstract: The creation and analysis of a large variety of existing methods for the evaluation of integrated antioxidant properties are quite relevant in connection with a range of biological mechanisms of the antioxidants (AO) action. In this work, the existing methods are correlated with mechanisms of antioxidant action. It is shown that the results obtained by various methods are mainly incomparable. This can be connected with the implementation of various mechanisms of antioxidant action in methods. The analysis of the literature data presented in this review indicates the difficulty of creating a universal method and the feasibility of using integrated approaches based on the use of several methods that implement and combine various mechanisms of the chemical conversion of antioxidants. This review describes methods for studying the chelating ability of antioxidants, except for methods based on electron and hydrogen atom transfer reactions, which are currently not widely covered in modern literature. With the description of each mechanism, special attention is paid to electrochemical methods, as the interaction of active oxygen metabolites of radical and non-radical nature with antioxidants has an electron/proton/donor-acceptor nature, which corresponds to the nature of electrochemical methods and suggests that they can be used to study the interaction. © 2020 by the authors.
Keywords: ANTIOXIDANT CAPACITY
CHELATING-BASED ASSAYS
ELECTROCHEMICAL METHODS
ELECTRON-TRANSFER-BASED ASSAYS
HYDROGEN ATOM TRANSFER-BASED ASSAYS
ANTIOXIDANT
CHELATING AGENT
REACTIVE OXYGEN METABOLITE
CHEMISTRY
ELECTROCHEMICAL ANALYSIS
ELECTRON
METABOLISM
OXIDATION REDUCTION REACTION
ANTIOXIDANTS
CHELATING AGENTS
ELECTROCHEMICAL TECHNIQUES
ELECTRONS
OXIDATION-REDUCTION
REACTIVE OXYGEN SPECIES
URI: http://hdl.handle.net/10995/101442
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85091323828
PURE ID: 13910578
341380c0-d9f2-477b-8be8-fb05fedbc9d3
ISSN: 14203049
DOI: 10.3390/molecules25184251
metadata.dc.description.sponsorship: This work was financially supported by the Russian Science Foundation (Project No. 20-13-00142).
RSCF project card: 20-13-00142
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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