SYNTHESIS OF BIOLOGICAL ACTIVE AZINYLFERROCENE DERIVATIVES

Abstract

As a rule, the presence of a lipophilic ferrocene unit in the drug structure modulates, and often enhances, their physiological activity. In this work the synthesis of vinyl-containing azinylferrocene derivatives was presented. It was found that previously obtained by direct C-H functionalization in (hetero)azinylferrocenes 1a-d (SN H reactions) undergo regioselective Friedel-Crafts acetylation to form 1, 1'-disubstituted 2a-d products with good yields, which are able to enter the Wittig reaction to the corresponding vinylferrocenes 3a-d.