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dc.contributor.authorFilatova, T. S.en
dc.contributor.authorAbramochkin, D. V.en
dc.contributor.authorShiels, H. A.en
dc.date.accessioned2020-09-29T09:45:47Z-
dc.date.available2020-09-29T09:45:47Z-
dc.date.issued2019-
dc.identifier.citationFilatova, T. S. Thermal acclimation and seasonal acclimatization: A comparative study of cardiac response to prolonged temperature change in shorthorn sculpin / T. S. Filatova, D. V. Abramochkin, H. A. Shiels. — DOI 10.1242/jeb.202242 // Journal of Experimental Biology. — 2019. — Vol. 16. — Iss. 222. — jeb202242.en
dc.identifier.issn0022-0949-
dc.identifier.otherhttps://jeb.biologists.org/content/jexbio/222/16/jeb202242.full.pdfpdf
dc.identifier.other1good_DOI
dc.identifier.other24945a57-64db-4a57-b533-a34d50d660abpure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85071707207m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/90053-
dc.description.abstractSeasonal thermal remodelling (acclimatization) and laboratory thermal remodelling (acclimation) can induce different physiological changes in ectothermic animals. As global temperatures are changing at an increasing rate, there is urgency to understand the compensatory abilities of key organs such as the heart to adjust under natural conditions. Thus, the aim of the present study was to directly compare the acclimatization and acclimatory response within a single eurythermal fish species, the European shorthorn sculpin (Myoxocephalus scorpio). We used current- and voltage-clamp to measure ionic current densities in both isolated atrial and ventricular myocytes from three groups of fish: (1) summer-caught fish kept at 12°C (‘summer-acclimated’); (2) summer-caught fish kept at 3°C (‘cold acclimated’); and (3) fish caught in March (‘winter-acclimatized’). At a common test temperature of 7.5°C, action potential (AP) was shortened by both winter acclimatization and cold acclimation compared with summer acclimation; however, winter acclimatization caused a greater shortening than did cold acclimation. Shortening of AP was achieved mostly by a significant increase in repolarizing current density (IKr and IK1) following winter acclimatization, with cold acclimation having only minor effects. Compared with summer acclimation, the depolarizing L-type calcium current (ICa) was larger following winter acclimatization, but again, there was no effect of cold acclimation on ICa. Interestingly, the other depolarizing current, INa, was downregulated at low temperatures. Our further analysis shows that ionic current remodelling is primarily due to changes in ion channel density rather than current kinetics. In summary, acclimatization profoundly modified the electrical activity of the sculpin heart while acclimation to the same temperature for >1.5 months produced very limited remodelling effects. © 2019. Published by The Company of Biologists Ltd.en
dc.description.sponsorshipRussian Foundation for Basic Research, RFBR: 18-315-20049en
dc.description.sponsorshipThe study was supported by the Russian Foundation for Basic Research (18-315-20049 to D.V.A.).en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherCompany of Biologists Ltden
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceJournal of Experimental Biologyen
dc.subjectACTION POTENTIALen
dc.subjectELECTROPHYSIOLOGYen
dc.subjectHEARTen
dc.subjectHYPERTROPHYen
dc.subjectMYOXOCEPHALUS SCORPIOen
dc.subjectTHERMAL REMODELLINGen
dc.subjectACCLIMATIZATIONen
dc.subjectACTION POTENTIALen
dc.subjectANIMALen
dc.subjectCARDIAC MUSCLE CELLen
dc.subjectFISHen
dc.subjectHEATen
dc.subjectHEAT TOLERANCEen
dc.subjectPHYSIOLOGYen
dc.subjectSEASONen
dc.subjectACCLIMATIZATIONen
dc.subjectACTION POTENTIALSen
dc.subjectANIMALSen
dc.subjectFISHESen
dc.subjectHOT TEMPERATUREen
dc.subjectMYOCYTES, CARDIACen
dc.subjectSEASONSen
dc.subjectTHERMOTOLERANCEen
dc.titleThermal acclimation and seasonal acclimatization: A comparative study of cardiac response to prolonged temperature change in shorthorn sculpinen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1242/jeb.202242-
dc.identifier.scopus85071707207-
local.affiliationDepartment of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russian Federationen
local.affiliationDepartment of Physiology, Russian National Research Medical University, Ostrovityanova str., 1, Moscow, 117997, Russian Federationen
local.affiliationUral Federal University, Mira 19, Ekaterinburg, 620002, Russian Federationen
local.affiliationFaculty of Life Sciences, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, United Kingdomen
local.contributor.employeeFilatova, T.S., Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russian Federation, Department of Physiology, Russian National Research Medical University, Ostrovityanova str., 1, Moscow, 117997, Russian Federationru
local.contributor.employeeAbramochkin, D.V., Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russian Federation, Department of Physiology, Russian National Research Medical University, Ostrovityanova str., 1, Moscow, 117997, Russian Federation, Ural Federal University, Mira 19, Ekaterinburg, 620002, Russian Federationru
local.contributor.employeeShiels, H.A., Faculty of Life Sciences, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, United Kingdomru
local.issue222-
local.volume16-
dc.identifier.wos000484368200004-
local.identifier.pure10768470-
local.description.orderjeb202242-
local.identifier.eid2-s2.0-85071707207-
local.fund.rffi18-315-20049-
local.identifier.wosWOS:000484368200004-
Располагается в коллекциях:Научные публикации, проиндексированные в SCOPUS и WoS CC

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