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Поле DC | Значение | Язык |
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dc.contributor.author | Filatova, T. S. | en |
dc.contributor.author | Abramochkin, D. V. | en |
dc.contributor.author | Shiels, H. A. | en |
dc.date.accessioned | 2020-09-29T09:45:47Z | - |
dc.date.available | 2020-09-29T09:45:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Filatova, T. S. Thermal acclimation and seasonal acclimatization: A comparative study of cardiac response to prolonged temperature change in shorthorn sculpin / T. S. Filatova, D. V. Abramochkin, H. A. Shiels. — DOI 10.1242/jeb.202242 // Journal of Experimental Biology. — 2019. — Vol. 16. — Iss. 222. — jeb202242. | en |
dc.identifier.issn | 0022-0949 | - |
dc.identifier.other | https://jeb.biologists.org/content/jexbio/222/16/jeb202242.full.pdf | |
dc.identifier.other | 1 | good_DOI |
dc.identifier.other | 24945a57-64db-4a57-b533-a34d50d660ab | pure_uuid |
dc.identifier.other | http://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85071707207 | m |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/90053 | - |
dc.description.abstract | Seasonal thermal remodelling (acclimatization) and laboratory thermal remodelling (acclimation) can induce different physiological changes in ectothermic animals. As global temperatures are changing at an increasing rate, there is urgency to understand the compensatory abilities of key organs such as the heart to adjust under natural conditions. Thus, the aim of the present study was to directly compare the acclimatization and acclimatory response within a single eurythermal fish species, the European shorthorn sculpin (Myoxocephalus scorpio). We used current- and voltage-clamp to measure ionic current densities in both isolated atrial and ventricular myocytes from three groups of fish: (1) summer-caught fish kept at 12°C (‘summer-acclimated’); (2) summer-caught fish kept at 3°C (‘cold acclimated’); and (3) fish caught in March (‘winter-acclimatized’). At a common test temperature of 7.5°C, action potential (AP) was shortened by both winter acclimatization and cold acclimation compared with summer acclimation; however, winter acclimatization caused a greater shortening than did cold acclimation. Shortening of AP was achieved mostly by a significant increase in repolarizing current density (IKr and IK1) following winter acclimatization, with cold acclimation having only minor effects. Compared with summer acclimation, the depolarizing L-type calcium current (ICa) was larger following winter acclimatization, but again, there was no effect of cold acclimation on ICa. Interestingly, the other depolarizing current, INa, was downregulated at low temperatures. Our further analysis shows that ionic current remodelling is primarily due to changes in ion channel density rather than current kinetics. In summary, acclimatization profoundly modified the electrical activity of the sculpin heart while acclimation to the same temperature for >1.5 months produced very limited remodelling effects. © 2019. Published by The Company of Biologists Ltd. | en |
dc.description.sponsorship | Russian Foundation for Basic Research, RFBR: 18-315-20049 | en |
dc.description.sponsorship | The study was supported by the Russian Foundation for Basic Research (18-315-20049 to D.V.A.). | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | Company of Biologists Ltd | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.source | Journal of Experimental Biology | en |
dc.subject | ACTION POTENTIAL | en |
dc.subject | ELECTROPHYSIOLOGY | en |
dc.subject | HEART | en |
dc.subject | HYPERTROPHY | en |
dc.subject | MYOXOCEPHALUS SCORPIO | en |
dc.subject | THERMAL REMODELLING | en |
dc.subject | ACCLIMATIZATION | en |
dc.subject | ACTION POTENTIAL | en |
dc.subject | ANIMAL | en |
dc.subject | CARDIAC MUSCLE CELL | en |
dc.subject | FISH | en |
dc.subject | HEAT | en |
dc.subject | HEAT TOLERANCE | en |
dc.subject | PHYSIOLOGY | en |
dc.subject | SEASON | en |
dc.subject | ACCLIMATIZATION | en |
dc.subject | ACTION POTENTIALS | en |
dc.subject | ANIMALS | en |
dc.subject | FISHES | en |
dc.subject | HOT TEMPERATURE | en |
dc.subject | MYOCYTES, CARDIAC | en |
dc.subject | SEASONS | en |
dc.subject | THERMOTOLERANCE | en |
dc.title | Thermal acclimation and seasonal acclimatization: A comparative study of cardiac response to prolonged temperature change in shorthorn sculpin | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1242/jeb.202242 | - |
dc.identifier.scopus | 85071707207 | - |
local.affiliation | Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russian Federation | en |
local.affiliation | Department of Physiology, Russian National Research Medical University, Ostrovityanova str., 1, Moscow, 117997, Russian Federation | en |
local.affiliation | Ural Federal University, Mira 19, Ekaterinburg, 620002, Russian Federation | en |
local.affiliation | Faculty of Life Sciences, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, United Kingdom | en |
local.contributor.employee | Filatova, T.S., Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russian Federation, Department of Physiology, Russian National Research Medical University, Ostrovityanova str., 1, Moscow, 117997, Russian Federation | ru |
local.contributor.employee | Abramochkin, D.V., Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russian Federation, Department of Physiology, Russian National Research Medical University, Ostrovityanova str., 1, Moscow, 117997, Russian Federation, Ural Federal University, Mira 19, Ekaterinburg, 620002, Russian Federation | ru |
local.contributor.employee | Shiels, H.A., Faculty of Life Sciences, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, United Kingdom | ru |
local.issue | 222 | - |
local.volume | 16 | - |
dc.identifier.wos | 000484368200004 | - |
local.identifier.pure | 10768470 | - |
local.description.order | jeb202242 | - |
local.identifier.eid | 2-s2.0-85071707207 | - |
local.fund.rffi | 18-315-20049 | - |
local.identifier.wos | WOS:000484368200004 | - |
Располагается в коллекциях: | Научные публикации, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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10.1242-jeb.202242.pdf | 1,8 MB | Adobe PDF | Просмотреть/Открыть |
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