Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/112215
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dc.contributor.authorUsachev, S. A.en
dc.contributor.authorNigamatova, D. I.en
dc.contributor.authorMysik, D. K.en
dc.contributor.authorNaumov, N. A.en
dc.contributor.authorObydennov, D. L.en
dc.contributor.authorSosnovskikh, V. Y.en
dc.date.accessioned2022-05-12T08:30:44Z-
dc.date.available2022-05-12T08:30:44Z-
dc.date.issued2021-
dc.identifier.citation2-aryl-6-Polyfluoroalkyl-4-Pyrones as Promising Rf-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles / S. A. Usachev, D. I. Nigamatova, D. K. Mysik et al. // Molecules. — 2021. — Vol. 26. — Iss. 15. — 4415.en
dc.identifier.issn1420-3049-
dc.identifier.otherAll Open Access, Green3
dc.identifier.urihttp://hdl.handle.net/10995/112215-
dc.description.abstractA convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4-diones via a bromination/dehy-drobromination approach. This strategy was also applied for the preparation of 2-phenyl-6-polyfluoroalkyl-4-pyrones and their 5-bromo derivatives. Conditions of chemoselective enediones bromination were found and the key intermediates of the cyclization of bromo-derivatives to 4-pyrones were characterized. Synthetic application of the prepared 4-pyrones has been demonstrated for the construction of biologically important CF3-bearing azaheterocycles, such as pyra-zoles, pyridones, and triazoles. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.description.sponsorshipFunding: This research was funded by the Russian Science Foundation, grant number 18-13-00186.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPI AGen1
dc.publisherMDPI AGen
dc.relationinfo:eu-repo/grantAgreement/RSF//18-13-00186en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceMolecules2
dc.sourceMoleculesen
dc.subject4-PYRONESen
dc.subjectFLUORINATED HETEROCYCLESen
dc.subjectREGIOSELECTIVE BROMINATIONen
dc.subjectΒ-DIKETONESen
dc.title2-aryl-6-Polyfluoroalkyl-4-Pyrones as Promising Rf-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocyclesen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.scopus85112031440-
local.contributor.employeeUsachev, S.A., Institute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federation; Nigamatova, D.I., Institute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federation; Mysik, D.K., Institute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federation; Naumov, N.A., Institute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federation; Obydennov, D.L., Institute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federation; Sosnovskikh, V.Y., Institute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federationen
local.issue15-
local.volume26-
local.contributor.departmentInstitute of Natural Sciences and Mathematics, Ural Federal University, 51 Lenina Ave, Ekaterinburg, 620000, Russian Federationen
local.identifier.pure22983685-
local.description.order4415-
local.identifier.eid2-s2.0-85112031440-
local.fund.rsf18-13-00186-
local.identifier.pmid34361567
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