Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/111403
Title: Evaluation of the Ophthalmotoxic Effect of Quantum Dots and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research (Stage 1)
Other Titles: Оценка офтальмотоксического воздействия квантовых точек и биоконъюгатов на их основе в аспекте перспектив лечения резистентных эндофтальмитов. Экспериментальное исследование (1-й этап)
Authors: Ponomarev, V. O.
Kazaykin, V. N.
Lizunov, A. V.
Vokhmintsev, A. S.
Vainshtein, I. A.
Dezhurov, S. V.
Issue Date: 2021
Publisher: Ophthalmology Publishing Group
PE Polunina Elizareta Gennadievna
Citation: Evaluation of the Ophthalmotoxic Effect of Quantum Dots and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research (Stage 1) [Оценка офтальмотоксического воздействия квантовых точек и биоконъюгатов на их основе в аспекте перспектив лечения резистентных эндофтальмитов. Экспериментальное исследование (1-й этап)] / V. O. Ponomarev, V. N. Kazaykin, A. V. Lizunov et al. // Oftalmologiya. — 2021. — Vol. 18. — Iss. 3. — P. 476-487.
Abstract: Endophthalmitis remains one of the most formidable complications of surgery in ophthalmology, leading to significant functional and anatomical changes. The "gold" standard of treatment for this pathology is the installation of intravenous injections of antibacterial drugs, but taking into account the number and type of pathogens, the growth of antibiotic resistance, the search for alternative methods of treatment of endophthalmitis remains relevant. Colloidal quantum dots, which are nanoscale semiconductor crystals with simulated optical and electronic properties due to changes in their volume, composition, and surface connections, are of interest for research in this direction. This article presents the process of synthesis of CT and bioconjugates based on them in order to assess ophthalmotoxicity with the prospect of further use in the treatment of endophthalmitis. The study was divided into 4 stages, starting with the determination of the required technical specification in order to select the appropriate type of quantum dots taking into account the physical and chemical characteristics (Stage 1), the synthesis of quantum dots (Stage 2), the preparation and titration of a solution of quantum dots of various concentrations for implantation in the vitreous cavity (Stage 3). The final stage was to evaluate the toxic effect of the quantum dot solution in its pure form, as well as in combination with antibiotics (ceftazidime and vancomycin) when administered intravitreally on an animal model. As a result of the study, quantum dots were synthesized and a solution based on them was obtained for introduction into the vitreous cavity. Based on the testing of the animal model (rabbits), a safe dose of the solution was determined, as well as the possibility of its use in combination with antibiotics. © 2021 Ophthalmology Publishing Group. All rights reserved.
Keywords: BIOCONJUGATES
ELECTRORETINOGRAPHY
ENDOPHTHALMITIS
INTRAVITREAL INJECTIONS
QUANTUM DOTS
TOXICOGOLOGY
CEFTAZIDIME
QUANTUM DOT
VANCOMYCIN
ANIMAL MODEL
ANTIBIOTIC RESISTANCE
ARTICLE
COMPUTER ASSISTED TOMOGRAPHY
CRYSTAL
ENDOPHTHALMITIS
EYE TOXICITY
HUMAN
NONHUMAN
SURFACE PROPERTY
SYNTHESIS
TITRIMETRY
VITREOUS BODY
VOLUME
URI: http://hdl.handle.net/10995/111403
Access: info:eu-repo/semantics/openAccess
SCOPUS ID: 85119058915
PURE ID: 23824634
ISSN: 1816-5095
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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