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http://elar.urfu.ru/handle/10995/111179
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Поле DC | Значение | Язык |
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dc.contributor.author | Kulikova, T. | en |
dc.contributor.author | Porfireva, A. | en |
dc.contributor.author | Rogov, A. | en |
dc.contributor.author | Evtugyn, G. | en |
dc.date.accessioned | 2022-05-12T08:14:00Z | - |
dc.date.available | 2022-05-12T08:14:00Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Electrochemical DNA Sensor Based on Acridine Yellow Adsorbed on Glassy Carbon Electrode / T. Kulikova, A. Porfireva, A. Rogov et al. // Sensors. — 2021. — Vol. 21. — Iss. 22. — 7763. | en |
dc.identifier.issn | 1424-8220 | - |
dc.identifier.other | All Open Access, Gold, Green | 3 |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/111179 | - |
dc.description.abstract | Electrochemical DNA sensors offer unique opportunities for the sensitive detection of specific DNA interactions. In this work, a voltametric DNA sensor is proposed on the base of glassy carbon electrode modified with carbon black, adsorbed acridine yellow and DNA for highly sensitive determination of doxorubicin antitumor drug. The signal recorded by cyclic voltammetry was attributed to irreversible oxidation of the dye. Its value was altered by aggregation of the hydrophobic dye molecules on the carbon black particles. DNA molecules promote disaggregation of the dye and increased the signal. This effect was partially suppressed by doxorubicin compensate for the charge of DNA in the intercalation. Sensitivity of the signal toward DNA and doxorubicin was additionally increased by treatment of the layer with dimethylformamide. In optimal conditions, the linear range of doxorubicin concentrations determined was 0.1 pM–1.0 nM, and the detection limit was 0.07 pM. No influence of sulfonamide medicines and plasma electrolytes on the doxorubicin determination was shown. The DNA sensor was tested on two medications (doxorubicin-TEVA and doxorubicin-LANS) and showed recoveries of 102–105%. The DNA sensor developed can find applications in the determination of drug residues in blood and for the pharmacokinetics studies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.description.sponsorship | This research was funded by the Russian Science Foundation (A.P., grant no. 17-73-20024, investigations of DNA adsorption DMF influence and DNA-doxorubicin interactions) and the Russian Foundation for Basic Research (G.E., grant no. 20-03-00207, investigation of the AY electrochemical properties and its transfer on the electrode interface). | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | MDPI | en1 |
dc.publisher | MDPI AG | en |
dc.relation | info:eu-repo/grantAgreement/RSF//17-73-20024 | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.source | Sensors | 2 |
dc.source | Sensors | en |
dc.subject | CARBON BLACK | en |
dc.subject | CYCLIC VOLTAMMETRY | en |
dc.subject | DOXORUBICIN DETERMINATION | en |
dc.subject | DRUG DETERMINATION | en |
dc.subject | ELECTROCHEMICAL DNA SENSOR | en |
dc.subject | CARBON BLACK | en |
dc.subject | CHEMICAL DETECTION | en |
dc.subject | CYCLIC VOLTAMMETRY | en |
dc.subject | DIMETHYLFORMAMIDE | en |
dc.subject | GLASS | en |
dc.subject | GLASS MEMBRANE ELECTRODES | en |
dc.subject | SULFUR COMPOUNDS | en |
dc.subject | ANTITUMOR DRUGS | en |
dc.subject | DNA INTERACTION | en |
dc.subject | DNA SENSORS | en |
dc.subject | DOXORUBICIN | en |
dc.subject | DOXORUBICIN DETERMINATION | en |
dc.subject | DRUG DETERMINATION | en |
dc.subject | ELECTROCHEMICAL DNA SENSOR | en |
dc.subject | GLASSY CARBON ELECTRODES | en |
dc.subject | IRREVERSIBLE OXIDATION | en |
dc.subject | SENSITIVE DETECTION | en |
dc.subject | DNA | en |
dc.subject | ACRIDINE YELLOW | en |
dc.subject | AMINOACRIDINE DERIVATIVE | en |
dc.subject | CARBON | en |
dc.subject | DNA | en |
dc.subject | ELECTROCHEMICAL ANALYSIS | en |
dc.subject | ELECTRODE | en |
dc.subject | AMINOACRIDINES | en |
dc.subject | CARBON | en |
dc.subject | DNA | en |
dc.subject | ELECTROCHEMICAL TECHNIQUES | en |
dc.subject | ELECTRODES | en |
dc.title | Electrochemical DNA Sensor Based on Acridine Yellow Adsorbed on Glassy Carbon Electrode | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.3390/s21227763 | - |
dc.identifier.scopus | 85119334257 | - |
local.contributor.employee | Kulikova, T., A.M. Butlerov’ Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation; Porfireva, A., A.M. Butlerov’ Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation; Rogov, A., Interdisciplinary Center of Analytical Microscopy, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation; Evtugyn, G., A.M. Butlerov’ Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation, Analytical Chemistry Department, Chemical Technology Institute, Ural Federal University, 19 Mira Street, Ekaterinburg, 620002, Russian Federation | en |
local.issue | 22 | - |
local.volume | 21 | - |
dc.identifier.wos | 000725498500001 | - |
local.contributor.department | A.M. Butlerov’ Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation; Interdisciplinary Center of Analytical Microscopy, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation; Analytical Chemistry Department, Chemical Technology Institute, Ural Federal University, 19 Mira Street, Ekaterinburg, 620002, Russian Federation | en |
local.identifier.pure | 28943188 | - |
local.description.order | 7763 | - |
local.identifier.eid | 2-s2.0-85119334257 | - |
local.fund.rsf | 17-73-20024 | - |
local.fund.rffi | 20-03-00207 | - |
local.identifier.wos | WOS:000725498500001 | - |
local.identifier.pmid | 34833839 | - |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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2-s2.0-85119334257.pdf | 2,55 MB | Adobe PDF | Просмотреть/Открыть |
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