Исследование поздней авто деполяризации кардиомиоцитов на одномерной модели мышечного волокна

Abstract

In this work, we study the spontaneous activation of cardiomyocytes in 1D model of the myocardial tissue. The simulation use Noble (1998) electrophysiology model and open source software Oxford Chaste. In the computational experiments, we variate the space distribution of the parameters which influence to cardiomyocytes delayed afterdepolarization activity. The simulations show the significant influence of healthy-pathology border properties to frequency and features of premature excitation in the model.