Математическое моделирование влияния лидокаина на спонтанную электрическую активность сердца

Abstract

The Maltsev-Lakatta model reproduces the experimental data of cessation of action potential (AP) generation at high lidocaine concentration. The model predicts that the delayed activation of the L-type calcium current mostly contributes to the disturbances of the AP generation when selective sodium channel blocker, lidocaine was applied. Simulations show that an increase in L-type calcium channel conductivity of 0.8% led to the AP recovering when sodium channel conductivity was decreased by 40%.