Роль фактора XIIIa свертывающей системы крови в контракции кровяного сгустка

Abstract

The importance of Factor XIIIa for contraction of a blood clot was studied. Our data show that inhibition of the factor XIIIa transglutaminase activity by two different types of inhibitors (iodoacetamide and cystamine) dramatically impedes clot contraction dynamics without affecting the blood clot formation. These findings indicate that the enzymatic activity of factor XIIIa is essential for clot contraction in whole blood.