Различные стратегии ингибирования ренин-ангиотензиновой системы у крыс НИСАГ с наследственной индуцированной стрессом артериальной гипертонией

Abstract

Application of blockers of the renin-angiotensin system (RAS) is one of the most common ways to control the high SBP in patients with the appropriate pathology. Basic antihypertensive drugs that are available inhibit the action of the RAS and may be divided into two groups, angiotensin converting enzyme (ACE) blockers and angiotensin receptor type 1 inhibitors. Now available a new inhibitor aliskiren, acts at an earlier step. Aliskiren blocks renin, thereby inhibits the first step of the metabolism of angiotensinogen (Agt), the precursor of all angiotensin peptides.We compared the effect of all three types of drugs in hypertensive ISIAH rats in two age groups, thus simulating the use of various types of antihypertensive drugs by patients of different ages.