Влияние экспрессии адаптерного белка NEDD9 на агрессивность клеток эпителиального рака яичников мыши

Abstract

NEDD9 plays roles in focal adhesion signaling and cell motility. Aberrant expression of the protein is shown in progression of several different solid tumors. However, the role of NEDD9 in epithelial ovarian cancer (EOC) is poorly understood. Here, we studied how Nedd9 expression influences pro-tumorogenic and pro-metastatic features of murine EOC cells in vitro. Absence of Nedd9 expression increased cell motility and invasion of the cells, having no effect on their proliferation and adhesion. Our results implicate the roles of NEDD9 in EOC.