Влияние нокаута по фактору некроза опухоли на поведение и метаболизм биогенных аминов мозга

Abstract

In this study, we investigated the effect of knockout of tumor necrosis factor (TNF) gene on behavior and metabolism of biogenic amines in the brain. It was shown that knockout mice spend less time in Morris water maze in the sector where the platform was previously during probe trial. In the “novel object test” knockout mice sniff “object” less time than wild type mice. Furthermore, it was shown that the levels of 5-HIAA in the midbrain, the hippocampus and olfactory bulb significantly higher in knockout mice than in wild type mice.