Please use this identifier to cite or link to this item:
|Title:||Method development and validation of a reversed phase HPLC method for determination of Anastrazole and Temozolomide in pharmaceutical dosage form|
|Authors:||Akram, N. M. D.|
Gopal, N. M.
Reddy, N. B.
|Publisher:||American Institute of Physics Inc.|
|Citation:||Method development and validation of a reversed phase HPLC method for determination of Anastrazole and Temozolomide in pharmaceutical dosage form / N. M. D. Akram, N. M. Gopal, A. Balakrishna, et al. — DOI 10.1063/5.0018206 // AIP Conference Proceedings. — 2020. — Vol. 2280. — 0018206.|
|Abstract:||A new simple assay method has been developed and validated for the determination of Anastrazole and Temozolomide using reverse-phase high-performance liquid chromatography in their pharmaceutical dosage form. The chromatographic separation was performed on an Inertsil ODS (4.6 x 150mm, 5m) using mobile phase phosphate buffer pH 3.0 and methanol of 30:70% v/v at a flow rate of 0.8mL/min. Analytes were detected at 260nm. The method was found to be linear in the concentration range of 1-5μg/mL for both medicaments with the coefficient value (R2) of >0.999. The accuracy was measured via recovery studies and found to be acceptable and the percentage recoveries were found in the range of 98.81-100.720 and 99.290-100.700%. The proposed method was successfully validated and applied for the quantitative estimation of these drugs in both bulk and tablet dosage forms. © 2020 Author(s).|
|Appears in Collections:||Научные публикации, проиндексированные в SCOPUS и WoS CC|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.