Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/101520
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dc.contributor.authorLookin, O.en
dc.contributor.authorButova, X.en
dc.contributor.authorProtsenko, Y.en
dc.date.accessioned2021-08-31T14:57:53Z-
dc.date.available2021-08-31T14:57:53Z-
dc.date.issued2021-
dc.identifier.citationLookin O. The role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscle / O. Lookin, X. Butova, Y. Protsenko. — DOI 10.1016/j.pbiomolbio.2020.05.005 // Progress in Biophysics and Molecular Biology. — 2021. — Vol. 159. — P. 34-45.en
dc.identifier.issn796107-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access, Bronze3
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85085608865&doi=10.1016%2fj.pbiomolbio.2020.05.005&partnerID=40&md5=ed24ae564e7226104ad024ffbef43713
dc.identifier.otherhttps://doi.org/10.1016/j.pbiomolbio.2020.05.005m
dc.identifier.urihttp://hdl.handle.net/10995/101520-
dc.description.abstractMyocardial function is tuned by dynamic changes in length and load via mechano-calcium feedback. This regulation may be significantly affected by heart rhythm. We evaluated the mechano-induced modulation of contractility and Ca-transient (CaT) in the rat myocardium subjected to twitch-by-twitch shortening–re-lengthening (↓–↑) trains of different lengths (N = 1 … 720 cycles) at low (1 Hz) and near-physiological (3.5 Hz) pacing rates. Force/CaT characteristics were evaluated in the first post-train isometric twitch (immediate effect) and during slow changes (delayed maximal elevation/decrease) and compared with those of the pre-train twitch. The immediate inotropic effect was positive for N = 30 … 720 and negative for N = 1 … 20, while the delayed effect was always positive. The immediate and delayed inotropic effects were significantly higher at 3.5-Hz vs 1-Hz (P < 0.05). The prominent inotropism was accompanied by much smaller changes in the CaT diastolic level/amplitude. The shortening–re-lengthening train induced oscillations of the slow change in force at 3.5-Hz (always) and at 1-Hz (∼50% of muscles), which were dependent of the train length and independent of the pacing rate. We suggest that twitch-by-twitch shortening–re-lengthening of cardiac muscle decreases Ca2+ buffering by troponin C and elevates Ca2+ loading of the sarcoplasmic reticulum (SR); the latter cumulatively depends on the train length. A high pacing rate intensifies the cumulative transient shift in the SR Ca2+ loading, augmenting the post-train inotropic response and prolonging its recovery to the pre-train level. The pacing-dependent mechano-induced inotropic effects remain to be elucidated in the myocardium with impaired Ca handling. © 2020 Elsevier Ltden
dc.description.sponsorshipThe study was supported by RFBR grant # 18-04-00572 and by RF Government Act #211 of March 16, 2013 (agreement 02.A03.21.0006 ), and was carried out within the framework of the IIF UrB RAS theme No АААА-А18-118020590031-8 .en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherElsevier Ltden
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.sourceProg. Biophys. Mol. Biol.2
dc.sourceProgress in Biophysics and Molecular Biologyen
dc.subject(INTRA)CELLULAR CALCIUM BALANCEen
dc.subjectCALCIUM TRANSIENTen
dc.subjectMECHANO-CALCIUM FEEDBACKen
dc.subjectMYOCARDIUMen
dc.subjectSYSTOLIC SHORTENING–RE-LENGTHENINGen
dc.titleThe role of pacing rate in the modulation of mechano-induced immediate and delayed changes in the force and Ca-transient of cardiac muscleen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/j.pbiomolbio.2020.05.005-
dc.identifier.scopus85085608865-
local.contributor.employeeLookin, O., Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya St., Yekaterinburg, 620049, Russian Federation, Center for Fundamental Biotechnology and Bioengineering, Institute of Natural Sciences and Mathematics, Ural Federal University, 19 Mira St., Yekaterinburg, 620002, Russian Federation
local.contributor.employeeButova, X., Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya St., Yekaterinburg, 620049, Russian Federation, Center for Fundamental Biotechnology and Bioengineering, Institute of Natural Sciences and Mathematics, Ural Federal University, 19 Mira St., Yekaterinburg, 620002, Russian Federation
local.contributor.employeeProtsenko, Y., Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya St., Yekaterinburg, 620049, Russian Federation
local.description.firstpage34-
local.description.lastpage45-
local.volume159-
local.contributor.departmentInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya St., Yekaterinburg, 620049, Russian Federation
local.contributor.departmentCenter for Fundamental Biotechnology and Bioengineering, Institute of Natural Sciences and Mathematics, Ural Federal University, 19 Mira St., Yekaterinburg, 620002, Russian Federation
local.identifier.pure20517495-
local.identifier.pured8b5cb38-4319-4b66-9212-7db28d567414uuid
local.identifier.eid2-s2.0-85085608865-
local.fund.rffi18-04-00572-
local.identifier.pmid32450183-
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