1. Электронный научный архив УрФУ
  2. 00. Общеуниверситетские коллекции
  3. Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC
Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://elar.urfu.ru/handle/10995/90651
Полная запись метаданных
Поле DCЗначениеЯзык
dc.contributor.authorBhuvaneswar, C.en
dc.contributor.authorRammohan, A.en
dc.contributor.authorBhaskar, B. V.en
dc.contributor.authorBabu, P. R.en
dc.contributor.authorNaveen, G.en
dc.contributor.authorGunasekar, D.en
dc.contributor.authorMadhuri, S.en
dc.contributor.authorReddanna, P.en
dc.contributor.authorRajendra, W.en
dc.date.accessioned2020-09-29T09:48:15Z-
dc.date.available2020-09-29T09:48:15Z-
dc.date.issued2020-
dc.identifier.citationSophora interruptaBedd. root-derived flavonoids as prominent antiviral agents against Newcastle disease virus / C. Bhuvaneswar, A. Rammohan, B. V. Bhaskar, P. R. Babu, et al. . — DOI 10.1039/d0ra01820a // RSC Advances. — 2020. — Vol. 55. — Iss. 10. — P. 33534-33543.en
dc.identifier.issn2046-2069-
dc.identifier.otherhttps://pubs.rsc.org/en/content/articlepdf/2020/ra/d0ra01820apdf
dc.identifier.other1good_DOI
dc.identifier.other22754e36-ae2e-4798-a971-5e87dc88ba50pure_uuid
dc.identifier.otherhttp://www.scopus.com/inward/record.url?partnerID=8YFLogxK&scp=85090999154m
dc.identifier.urihttp://elar.urfu.ru/handle/10995/90651-
dc.description.abstractThe discovery and development of novel antiviral drugs from natural sources is continuously increasing due to limitations of currently available drugs such as toxic side effects, drug residue risk factors, high costs, and poor therapeutic strategies. Also, there are very few known antiviral drugs that are effective against only specific viruses. Hence, the present study is intended to isolate and characterize potent antiviral compounds from the methanolic root extract ofSophora interruptaBedd. against avian paramyxovirus, Newcastle disease virus (NDV) and to distinguish the molecular basis of antiviral compounds. The two isolated flavonoids, maackiain (SR-1) and echinoisoflavanone (SR-2) exhibited the best antiviral activities against NDV infection in chicken embryo fibroblast cell lines compared to the standard antiviral drug, Ribavirin. Further, thein vitrostudies and quantitative PCR analysis suggests that these flavonoids inhibit the viral entry, replication, and transcription, which may be beneficial as a promising strategy for the treatment of viral infections. Besides, the molecular docking studies ofSR-1andSR-2exhibited high binding affinities of −7.6 and −8.0 kcal mol−1, respectively, and marked interactions with the NDV surface glycoprotein, hemagglutinin neuraminidase (HN). Also, thein silicotoxicity properties as well pharmacokinetic studies of isolates revealed them as pharmacologically potent antiviral compounds. © The Royal Society of Chemistry 2020.en
dc.description.sponsorshipCouncil of Scientific and Industrial Research, India, CSIRen
dc.description.sponsorshipThe author WR thanks the Council of Scientic and Industrial Research (CSIR), New Delhi and the authors CB, AR, and PR are grateful to UGC-BSR, New Delhi for nancial assistance under CSIR-MRP and UGC-RFSMS (BSR) programs. Furthermore, all the authors are thankful to National Institute of Animal Biotechnology (NIAB), Hyderabad for providing laboratory facilities to carry out the viral studies.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightscc-by-ncother
dc.sourceRSC Advancesen
dc.subjectAMIDESen
dc.subjectBINDING ENERGYen
dc.subjectCELL CULTUREen
dc.subjectDRUG INTERACTIONSen
dc.subjectFLAVONOIDSen
dc.subjectPOLYMERASE CHAIN REACTIONen
dc.subjectVIRUSESen
dc.subjectANTIVIRAL ACTIVITIESen
dc.subjectANTIVIRAL COMPOUNDen
dc.subjectBINDING AFFINITIESen
dc.subjectNEWCASTLE DISEASE VIRUSen
dc.subjectPHARMACOKINETIC STUDIESen
dc.subjectSURFACE GLYCOPROTEINSen
dc.subjectTHERAPEUTIC STRATEGYen
dc.subjectTOXIC SIDE EFFECTSen
dc.subjectANTIVIRAL AGENTSen
dc.titleSophora interruptaBedd. root-derived flavonoids as prominent antiviral agents against Newcastle disease virusen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1039/d0ra01820a-
dc.identifier.scopus85090999154-
local.affiliationDepartment of Zoology, Sri Venkateswara University, Tirupati, AP 517502, Indiaen
local.affiliationNatural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, AP 517502, Indiaen
local.affiliationNational Institute of Animal Biotechnology (NIAB), Hyderabad, AP 500049, Indiaen
local.affiliationDepartment of Microbiology, Sri Venkateswara University, Tirupati, AP 517502, Indiaen
local.affiliationDepartment of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, 620002, Russian Federationen
local.affiliationSchool of Life Sciences, University of Hyderabad (UOH), Hyderabad, Telangana 500046, Indiaen
local.affiliationDepartment of Pathophysiology, Shantou University Medical College, Shantou, Guangdong, Chinaen
local.contributor.employeeBhuvaneswar, C., Department of Zoology, Sri Venkateswara University, Tirupati, AP 517502, India, Department of Microbiology, Sri Venkateswara University, Tirupati, AP 517502, Indiaru
local.contributor.employeeRammohan, A., Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, AP 517502, India, Department of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, 620002, Russian Federationru
local.contributor.employeeBhaskar, B.V., Department of Pathophysiology, Shantou University Medical College, Shantou, Guangdong, Chinaru
local.contributor.employeeBabu, P.R., Department of Zoology, Sri Venkateswara University, Tirupati, AP 517502, Indiaru
local.contributor.employeeNaveen, G., National Institute of Animal Biotechnology (NIAB), Hyderabad, AP 500049, Indiaru
local.contributor.employeeGunasekar, D., Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, AP 517502, Indiaru
local.contributor.employeeMadhuri, S., National Institute of Animal Biotechnology (NIAB), Hyderabad, AP 500049, Indiaru
local.contributor.employeeReddanna, P., School of Life Sciences, University of Hyderabad (UOH), Hyderabad, Telangana 500046, Indiaru
local.contributor.employeeRajendra, W., Department of Zoology, Sri Venkateswara University, Tirupati, AP 517502, Indiaru
local.description.firstpage33534-
local.description.lastpage33543-
local.issue10-
local.volume55-
dc.identifier.wos000568227200056-
local.identifier.pure13910908-
local.identifier.eid2-s2.0-85090999154-
local.identifier.wosWOS:000568227200056-
Располагается в коллекциях:Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC

Файлы этого ресурса:
Файл Описание РазмерФормат 
10.1039-d0ra01820a.pdf1,18 MBAdobe PDFПросмотреть/Открыть
Показать базовое описание ресурса Статистика  Google Scholar





Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.