Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/75103
Title: Zebrafish models in neuropsychopharmacology and CNS drug discovery
Authors: Khan, K. M.
Collier, A. D.
Meshalkina, D. A.
Kysil, E. V.
Khatsko, S. L.
Kolesnikova, T.
Morzherin, Y. Y.
Warnick, J. E.
Kalueff, A. V.
Echevarria, D. J.
Issue Date: 2017
Publisher: John Wiley and Sons Inc.
Citation: Zebrafish models in neuropsychopharmacology and CNS drug discovery / K. M. Khan, A. D. Collier, D. A. Meshalkina et al. // British Journal of Pharmacology. — 2017. — Vol. 174. — Iss. 13. — P. 1925-1944.
Abstract: Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets. © 2017 The British Pharmacological Society
Keywords: ALCOHOL
AMPHETAMINE DERIVATIVE
ANTICONVULSIVE AGENT
COCAINE
NEUROLEPTIC AGENT
NICOTINE
PSYCHEDELIC AGENT
SEDATIVE AGENT
CENTRAL NERVOUS SYSTEM AGENTS
ALZHEIMER DISEASE
AMYOTROPHIC LATERAL SCLEROSIS
ANIMAL MODEL
ANXIETY DISORDER
AUTOMATION
CENTRAL NERVOUS SYSTEM
DEPRESSION
DRUG ABUSE
DRUG SCREENING
DRUG SENSITIVITY
DRUG TARGETING
EPILEPSY
GENETIC MODEL
GENETIC SCREENING
HIGH THROUGHPUT SCREENING
NERVE DEGENERATION
NONHUMAN
PRIORITY JOURNAL
PSYCHOPHARMACOLOGY
PSYCHOSIS
REVIEW
ZEBRA FISH
ANIMAL
CENTRAL NERVOUS SYSTEM DISEASE
CHEMISTRY
DISEASE MODEL
DRUG DEVELOPMENT
MOLECULAR LIBRARY
PRECLINICAL STUDY
SYNTHESIS
THERAPEUTIC USE
ZEBRA FISH
ANIMALS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DISEASES
DISEASE MODELS, ANIMAL
DRUG DISCOVERY
DRUG EVALUATION, PRECLINICAL
SMALL MOLECULE LIBRARIES
ZEBRAFISH
URI: http://hdl.handle.net/10995/75103
metadata.dc.rights: info:eu-repo/semantics/openAccess
SCOPUS ID: 85017091455
WOS ID: WOS:000403299900005
PURE ID: 1924696
ISSN: 0007-1188
DOI: 10.1111/bph.13754
metadata.dc.description.sponsorship: The study was coordinated through the International Zebrafish Neuroscience Research Consortium (ZNRC), and this collaboration was funded by St. Petersburg State University, Ural Federal University and Guangdong Ocean University. A.V.K. is the Chair of ZNRC, and his research is supported by the Russian Foundation for Basic Research (RFBR) grant 16-04-00851.
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

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