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http://elar.urfu.ru/handle/10995/75069
Название: | Effects of pregnancy-specific β-1-glycoprotein on the helper T-cell response |
Авторы: | Timganova, V. Bochkova, M. Khramtsov, P. Kochurova, S. Rayev, M. Zamorina, S. |
Дата публикации: | 2019 |
Издатель: | Institut za Bioloska Istrazivanja |
Библиографическое описание: | Effects of pregnancy-specific β-1-glycoprotein on the helper T-cell response / V. Timganova, M. Bochkova, P. Khramtsov et al. // Archives of Biological Sciences. — 2019. — Vol. 71. — Iss. 2. — P. 369-378. |
Аннотация: | Pregnancy-specific β-1-glycoproteins (PSGs) are capable of regulating innate and adaptive immunity. As fetal antigens circulate in the blood of pregnant women, it is of particular interest to reveal the effects of PSGs on the differentiation of memory T cells in the context of maternal-fetal tolerance formation. We studied if, native PSG preparation affects helper T-cell proliferation, the frequencies of CD4+CD45R0+, CD4+CD45RA+, CD4+CD45RA+CD45R0+cells, naive CD45RA+CD45R0-CD62L+ cells (NAIVE), central memory CD45RA-CD45R0+CD62L+ cells (TCM), effector memory helper T cells (CD45RA-CD45R0+CD62L- (TEM) and CD45RA+CD45R0-CD62L- cells (TEMRA), together with IL-4 and IFN-γ production by all CD4+ T cells. The suppressive effect of PSG on helper T-cell proliferation was established. It was found that PSG does not influence the frequencies of CD45RA+ and CD45R0+ cells, while it decreased the percentage of CD45RA+CD45R0+ cells. PSG increased the percentage of NAIVE cells in culture, and prevented the conversion of these cells into TEMRA, without affecting the levels of TCM and TEM. In addition, PSG lowered the amount of IL-4 and IFN-γ in the supernatants of helper T-cell cultures. As TEMRA exhibit cytotoxic activity that is unfavorable during pregnancy, the revealed PSG effects may play a fetoprotective role in vivo. © 2019 by the Serbian Biological Society. |
Ключевые слова: | EFFECTOR MEMORY T CELLS HELPER T CELLS NAIVE CD4+T CELLS PREGNANCY-SPECIFIC Β-1-GLYCOPROTEIN RA+ EFFECTOR MEMORY T CELLS |
URI: | http://elar.urfu.ru/handle/10995/75069 |
Условия доступа: | info:eu-repo/semantics/openAccess |
Идентификатор SCOPUS: | 85067102884 |
Идентификатор WOS: | 000471069700019 |
Идентификатор PURE: | 10014330 |
ISSN: | 0354-4664 |
DOI: | 10.2298/ABS190122019T |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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Файл | Описание | Размер | Формат | |
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2-s2.0-85067102884.pdf | 718,13 kB | Adobe PDF | Просмотреть/Открыть |
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