Please use this identifier to cite or link to this item: http://hdl.handle.net/10995/51494
Title: Regioselective synthesis of 2- and 5-trifluoromethyl-or 2- and 5-difluoromethylpyrazolo[1,5-c]pyrimidines based on 7,7,7-trifluoro-or 7,7-difluoro-2,4,6-trioxoheptanoic and 6-trifluoromethyl-or 6- difluoromethylcomanic acids
Authors: Usachev, B. I.
Obydennov, D. L.
Sosnovskikh, V. Ya.
Issue Date: 2012
Citation: Usachev B. I. Regioselective synthesis of 2- and 5-trifluoromethyl-or 2- and 5-difluoromethylpyrazolo[1,5-c]pyrimidines based on 7,7,7-trifluoro-or 7,7-difluoro-2,4,6-trioxoheptanoic and 6-trifluoromethyl-or 6- difluoromethylcomanic acids / B. I. Usachev, D. L. Obydennov, V. Ya. Sosnovskikh // Russian Chemical Bulletin. — 2012. — Vol. 61. — № 8. — P. 1596-1602.
Abstract: 6-Tri- and 6-difluoromethylcomanic acids and their ethyl esters reacted with aminoguanidine, predominantly giving 5-RF-pyrazolo[1,5-c] pyrimidines, whereas the reaction of the openchain synthetic equivalents, i.e., ethyl 7,7,7-trifluoro- and 7,7-difluoro-2,4,6-trioxoheptanoates, with this polynucleophile allowed us to obtain regioselectively 2-RF- pyrazolo[1,5-c]pyrimidines. © 2012 Springer Science+Business Media New York.
Keywords: 6-TRIFLUOROMETHYLCOMANIC ACID AND ITS ETHYL ESTER
AMINOGUANIDINE
ETHYL 7,7,7-TRIFLUORO-2,4,6-TRIOXOHEPTANOATE
PYRAZOLO-[1,5-C]PYRIMIDINES
REGIOSELECTIVE SYNTHESIS
RING-CHAIN TAUTOMERISM
THIOSEMICARBAZIDE
URI: http://hdl.handle.net/10995/51494
metadata.dc.rights: info:eu-repo/semantics/restrictedAccess
SCOPUS ID: 84886784695
WOS ID: WOS:000321772100015
PURE ID: 1077724
ISSN: 1066-5285
DOI: 10.1007/s11172-012-0212-5
Appears in Collections:Научные публикации, проиндексированные в SCOPUS и WoS CC

Files in This Item:
File Description SizeFormat 
10.1007s11172-012-0212-5_2012.pdf370,74 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.