Synthesis of pharmacologically active hydrogels based on combined silicon and titanium polyolates

Abstract

The target synthesis of new biologically active hydrogels based on combined silicon and titanium polyolates was carried out. The optimum conditions for hydrogel formation and their composition were determined. The type of hydrogels and mechanisms of gelation depend on the nature of polyols: gels based on combined silicon and titanium polyethylene glycolates are polymeric and formed via the polycondensation mechanism, whereas gels based on combined silicon and titanium glycerolates are colloidal and formed via the coagulation-condensation mechanism. The combined hydrogels based on silicon dimethyl glycerolates and titanium tetraglycerolate exhibit enhanced transcutaneous, wound healing, and regenerating activity. © 2012 Springer Science+Business Media New York.