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http://elar.urfu.ru/handle/10995/131373
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Elmas, O. | en |
dc.contributor.author | Sahin, H. H. K. | en |
dc.contributor.author | Keskin, E. | en |
dc.contributor.author | Guven, B. | en |
dc.contributor.author | Uslu, Erdemir, R. | en |
dc.contributor.author | Almisned, G. | en |
dc.contributor.author | Zakaly, H. M. H. | en |
dc.contributor.author | Ene, A. | en |
dc.contributor.author | Tekin, H. O. | en |
dc.date.accessioned | 2024-04-08T11:06:57Z | - |
dc.date.available | 2024-04-08T11:06:57Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Elmas, O, Sahin, HHK, Keskin, E, Guven, B, Uslu Erdemir, R, Almisned, G, Zakaly, HMH, Ene, A & Tekin, HO 2022, 'Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue', Open chemistry, Том. 20, № 1, стр. 929-938. https://doi.org/10.1515/chem-2022-0205 | harvard_pure |
dc.identifier.citation | Elmas, O., Sahin, H. H. K., Keskin, E., Guven, B., Uslu Erdemir, R., Almisned, G., Zakaly, H. M. H., Ene, A., & Tekin, H. O. (2022). Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue. Open chemistry, 20(1), 929-938. https://doi.org/10.1515/chem-2022-0205 | apa_pure |
dc.identifier.issn | 2391-5420 | - |
dc.identifier.other | Final | 2 |
dc.identifier.other | All Open Access; Gold Open Access | 3 |
dc.identifier.other | https://www.degruyter.com/document/doi/10.1515/chem-2022-0205/pdf | 1 |
dc.identifier.other | https://www.degruyter.com/document/doi/10.1515/chem-2022-0205/pdf | |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/131373 | - |
dc.description.abstract | We report the radioprotective attitude of Annona muricata (AM) leaf extract as antioxidant material to prevent cellular damage in the ileum tissue. The protective effects of an ethyl acetate extract of AM leaves are comprehensively investigated against radiation-induced ileal damage in numerous rats. Thirty-two adult female rats were separated into 4 groups (3 intervention groups and 1 control) as follows: controls received 0.01 mL/kg distilled water, the AM group received 300 mg/kg AM leaf extract, the ionizing radiation (IR) group received a single dose of whole body radiation (8.3 Gy) after 0.01 mL/kg saline treatment, and the AM + IR group received 300 mg/kg AM leaf extract treatment and were subjected to whole body radiation (8.3 Gy) 1 h after the last gavage. All treatments are administered by oral gavage once a day for 9 days. At the end of the experiment, biochemical total oxidant status (TOS, interleukin-6, and caspase) and histological examinations are performed on blood samples as well as ileum tissue. TOS levels are found to be significantly high in rats, which received irradiation, and those in the AM group when compared to controls. These findings suggest that AM has radioprotective effects on ileum tissue, likely because of its antioxidative properties. The findings of this research may contribute to the minimizing of major side effects induced by excessive radiation exposure in patients undergoing radiotherapy and may serve as a significant impetus for further assessments. However, future studies are highly recommended to confirm safety and to determine extraction technique and dosage before human use can be considered. © 2022 Ozlem Elmas et al. | en |
dc.description.sponsorship | Dunarea de Jos” University of Galati, (RF 3621/2021) | en |
dc.description.sponsorship | Universitatea 'Dunărea de Jos' Galați, UDJG | en |
dc.description.sponsorship | Funding text 1: Funding information: The work of Antoaneta ENE and the APC were supported by Dunarea de Jos University of Galati, Romania through the grant no. RF 3621/2021. | en |
dc.description.sponsorship | Funding text 2: Author contributions: O.E., H.H.K.S., and H.O.T.: – conceptualization and methodology | en |
dc.description.sponsorship | E.K., B.G., G.A., and R.U.E.: validation | en |
dc.description.sponsorship | G.A. and H.M.H.Z.: formal analysis | en |
dc.description.sponsorship | O.E., H.H.K.S., E.K., B.G., and H.O.T.: writing and review | en |
dc.description.sponsorship | O.E., H.H.K.S., E.K., B.G., and A.E.: investigation | en |
dc.description.sponsorship | A.E.: funding acquisition through APC by “Dunarea de Jos” University of Galati, Romania through the grant no. RF 3621/2021. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | De Gruyter Open Ltd | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.rights | cc-by | other |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | unpaywall |
dc.source | Open Chemistry | 2 |
dc.source | Open Chemistry | en |
dc.subject | ANNONA MURICATA | en |
dc.subject | APOPTOSIS | en |
dc.subject | IRRADIATION | en |
dc.subject | OXIDATIVE STRESS | en |
dc.subject | RADIOPROTECTIVE | en |
dc.title | Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1515/chem-2022-0205 | - |
dc.identifier.scopus | 85139209329 | - |
local.contributor.employee | Elmas O., Department of Radiation Oncology, Bulent Ecevit University Practice and Research Hospital, Zonguldak, Turkey | en |
local.contributor.employee | Sahin H.H.K., Department of Pathology, Hitit University Corum Training and Research Hospital, Corum, Turkey | en |
local.contributor.employee | Keskin E., Department of Neurosurgery, Bulent Ecevit University Practice and Research Hospital, Zonguldak, Turkey | en |
local.contributor.employee | Guven B., Department of Biochemistry, Bulent Ecevit University Practice and Research Hospital, Zonguldak, Turkey | en |
local.contributor.employee | Uslu Erdemir R., Department of Nuclear Medicine, Zonguldak Bülent Ecevit University, Faculty of Medicine, Zonguldak, Turkey | en |
local.contributor.employee | Almisned G., Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia | en |
local.contributor.employee | Zakaly H.M.H., Institute of Physics and Technology, Ural Federal University, Ekaterinburg, 620002, Russian Federation, Physics Department, Faculty of Science, Al-Azhar University, Assiut, 71524, Egypt | en |
local.contributor.employee | Ene A., Department of Chemistry, Physics and Environment, INPOLDE Research Center, Faculty of Sciences and Environment, Dunarea de Jos University of Galati, 47 Domneasca Street, Galati, 800008, Romania | en |
local.contributor.employee | Tekin H.O., Department of Medical Diagnostic Imaging, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates, Computer Engineering Department, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, 34396, Turkey | en |
local.description.firstpage | 929 | - |
local.description.lastpage | 938 | - |
local.issue | 1 | - |
local.volume | 20 | - |
dc.identifier.wos | 000858415500001 | - |
local.contributor.department | Department of Radiation Oncology, Bulent Ecevit University Practice and Research Hospital, Zonguldak, Turkey | en |
local.contributor.department | Department of Pathology, Hitit University Corum Training and Research Hospital, Corum, Turkey | en |
local.contributor.department | Department of Neurosurgery, Bulent Ecevit University Practice and Research Hospital, Zonguldak, Turkey | en |
local.contributor.department | Department of Biochemistry, Bulent Ecevit University Practice and Research Hospital, Zonguldak, Turkey | en |
local.contributor.department | Department of Nuclear Medicine, Zonguldak Bülent Ecevit University, Faculty of Medicine, Zonguldak, Turkey | en |
local.contributor.department | Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia | en |
local.contributor.department | Institute of Physics and Technology, Ural Federal University, Ekaterinburg, 620002, Russian Federation | en |
local.contributor.department | Physics Department, Faculty of Science, Al-Azhar University, Assiut, 71524, Egypt | en |
local.contributor.department | Department of Chemistry, Physics and Environment, INPOLDE Research Center, Faculty of Sciences and Environment, Dunarea de Jos University of Galati, 47 Domneasca Street, Galati, 800008, Romania | en |
local.contributor.department | Department of Medical Diagnostic Imaging, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates | en |
local.contributor.department | Computer Engineering Department, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, 34396, Turkey | en |
local.identifier.pure | 30946439 | - |
local.identifier.pure | 29ea5996-3119-476e-b7dd-fb8cc353720c | uuid |
local.identifier.eid | 2-s2.0-85139209329 | - |
local.identifier.wos | WOS:000858415500001 | - |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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2-s2.0-85139209329.pdf | 4,5 MB | Adobe PDF | Просмотреть/Открыть |
Лицензия на ресурс: Лицензия Creative Commons