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Название: | Towards Zebrafish Models of CNS Channelopathies |
Авторы: | Kolesnikova, T. O. Demin, K. A. Costa, F. V. Zabegalov, K. N. de Abreu, M. S. Gerasimova, E. V. Kalueff, A. V. |
Дата публикации: | 2022 |
Издатель: | MDPI |
Библиографическое описание: | Kolesnikova, TO, Demin, KA, Costa, FV, Zabegalov, KN, de Abreu, MS, Gerasimova, EV & Kalueff, AV 2022, 'Towards Zebrafish Models of CNS Channelopathies', International Journal of Molecular Sciences, Том. 23, № 22, 13979. https://doi.org/10.3390/ijms232213979 Kolesnikova, T. O., Demin, K. A., Costa, F. V., Zabegalov, K. N., de Abreu, M. S., Gerasimova, E. V., & Kalueff, A. V. (2022). Towards Zebrafish Models of CNS Channelopathies. International Journal of Molecular Sciences, 23(22), [13979]. https://doi.org/10.3390/ijms232213979 |
Аннотация: | Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+, Na+, Ca2+ and Cl− by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish (Danio rerio) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis. Here, we discuss current prospects and challenges of developing genetic, pharmacological and other experimental models of major CNS channelopathies based on zebrafish. © 2022 by the authors. |
Ключевые слова: | ANIMAL MODEL BRAIN CHANNELOPATHY ION CHANNEL ZEBRAFISH ANIMALS BRAIN CHANNELOPATHIES DISEASE MODELS, ANIMAL EPILEPSY ZEBRAFISH CENTRAL NERVOUS SYSTEM AGENTS ION CHANNEL ANIMAL MODEL CENTRAL NERVOUS SYSTEM CHANNELOPATHY CENTRAL NERVOUS SYSTEM DISEASE EXPERIMENTAL DESIGN EXPERIMENTAL MODEL GENETICS NEURONAL CHANNELOPATHY NEUROPATHOLOGY NONHUMAN REVIEW ZEBRA FISH ANIMAL BRAIN CHANNELOPATHY DISEASE MODEL EPILEPSY ZEBRA FISH |
URI: | http://elar.urfu.ru/handle/10995/131237 |
Условия доступа: | info:eu-repo/semantics/openAccess cc-by |
Текст лицензии: | https://creativecommons.org/licenses/by/4.0/ |
Идентификатор SCOPUS: | 85142788186 |
Идентификатор WOS: | 000887378400001 |
Идентификатор PURE: | 32802257 49af393d-6b99-4c2d-b41f-b3921519982e |
ISSN: | 1661-6596 |
DOI: | 10.3390/ijms232213979 |
Сведения о поддержке: | Applied Genetics MIPT, (075-15-2021-684) SPSU, (93020614) Sirius University, (NRB-RND-2116) Funding text 1: The research partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). A.V.K.’s contribution was partially supported by the SPSU funding program (Project ID 93020614). Funding text 2: The study is supported by Sirius University budgetary funds (Project ID NRB-RND-2116). |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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2-s2.0-85142788186.pdf | 418,42 kB | Adobe PDF | Просмотреть/Открыть |
Лицензия на ресурс: Лицензия Creative Commons