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http://elar.urfu.ru/handle/10995/131221
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Zakaly, H. M. H. | en |
dc.contributor.author | Mostafa, M. Y. A. | en |
dc.contributor.author | Zhukovsky, M. | en |
dc.date.accessioned | 2024-04-08T11:05:51Z | - |
dc.date.available | 2024-04-08T11:05:51Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Zakaly, HMH, Mostafa, MYA & Zhukovsky, M 2022, 'Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment', International Journal of Drug Delivery Technology, Том. 12, № 4, стр. 1802-1807. https://doi.org/10.25258/ijddt.12.4.52 | harvard_pure |
dc.identifier.citation | Zakaly, H. MH., Mostafa, M. YA., & Zhukovsky, M. (2022). Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment. International Journal of Drug Delivery Technology, 12(4), 1802-1807. https://doi.org/10.25258/ijddt.12.4.52 | apa_pure |
dc.identifier.issn | 0975-4415 | - |
dc.identifier.other | Final | 2 |
dc.identifier.other | All Open Access; Bronze Open Access | 3 |
dc.identifier.other | https://doi.org/10.25258/ijddt.12.4.52 | 1 |
dc.identifier.other | https://doi.org/10.25258/ijddt.12.4.52 | |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/131221 | - |
dc.description.abstract | 177Lu is a lanthanide radionuclide. In recent years, the possibility of applying a drug based on the177Lu radionuclide as a palliative treatment for bone metastases has increased.177Lu has many prospects in terms of its applications in nuclear medicine. The high-energy beta particles and the relatively short half-life of the radionuclide are used to provide an effective treatment. In this work, a comparison of organ and tissue doses is performed with two different drugs:177Lu in an ionic radionuclide form and177Lu labeled methylene diphosphonate (177Lu-MDP).177Lu in an ionic form actively accumulates in the liver and bones. Phosphonate compounds form stable radio-labeled complexes. This suggests that177Lu-MDP is a non-dissociated form of the drug. The distribution and elimination of the drug occur according to the kinetics of the carrier, i.e., methylene diphosphonate. It is shown that the use of an osteotropic complex (describing any drug that is attracted to and targets bone) allows for the concentration of a large dose in pathological areas and minimizes damage to healthy organs and tissues. © 2022, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | Dr. Yashwant Research Labs Pvt. Ltd. | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.source | INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY | 2 |
dc.source | International Journal of Drug Delivery Technology | en |
dc.subject | 177LU | en |
dc.subject | BONE METASTASIS | en |
dc.subject | METHYLENE DIPHOSPHONATE (MDP) | en |
dc.subject | PALLIATIVE THERAPY | en |
dc.subject | RADIONUCLIDE THERAPY | en |
dc.subject | RADIOPHARMACEUTICAL | en |
dc.subject | LANTHANIDE | en |
dc.subject | LUTETIUM 177 | en |
dc.subject | MEDRONIC ACID | en |
dc.subject | RADIOISOTOPE | en |
dc.subject | RADIOPHARMACEUTICAL AGENT | en |
dc.subject | ARTICLE | en |
dc.subject | BIOKINETIC MODEL | en |
dc.subject | BONE METASTASIS | en |
dc.subject | IONIZING RADIATION | en |
dc.subject | KINETICS | en |
dc.subject | PALLIATIVE THERAPY | en |
dc.subject | RADIATION PROTECTION | en |
dc.subject | RADIOCHEMISTRY | en |
dc.title | Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.25258/ijddt.12.4.52 | - |
dc.identifier.scopus | 85145924875 | - |
local.contributor.employee | Zakaly H.M.H., Physics department, Faculty of Science, Al-Azhar University, Assiut Branch, Egypt, Experimental hysics department, Institute of Physics and Technology, Ural Federal University, Yekaterinburg, Russian Federation | en |
local.contributor.employee | Mostafa M.Y.A., Physics department, Faculty of Science, Minia University, El-Minia, Egypt, Experimental hysics department, Institute of Physics and Technology, Ural Federal University, Yekaterinburg, Russian Federation | en |
local.contributor.employee | Zhukovsky M., Institute of Industrial Ecology UB RAS, Sophy Kovalevskoy St., 20, Ekaterinburg, 620990, Russian Federation | en |
local.description.firstpage | 1802 | - |
local.description.lastpage | 1807 | - |
local.issue | 4 | - |
local.volume | 12 | - |
local.contributor.department | Physics department, Faculty of Science, Al-Azhar University, Assiut Branch, Egypt | en |
local.contributor.department | Physics department, Faculty of Science, Minia University, El-Minia, Egypt | en |
local.contributor.department | Experimental hysics department, Institute of Physics and Technology, Ural Federal University, Yekaterinburg, Russian Federation | en |
local.contributor.department | Institute of Industrial Ecology UB RAS, Sophy Kovalevskoy St., 20, Ekaterinburg, 620990, Russian Federation | en |
local.identifier.pure | 33318536 | - |
local.identifier.pure | 0d45b94a-e1a1-43ab-b498-25a6eaac6fac | uuid |
local.identifier.eid | 2-s2.0-85145924875 | - |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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2-s2.0-85145924875.pdf | 440,34 kB | Adobe PDF | Просмотреть/Открыть |
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