1. Электронный научный архив УрФУ
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dc.contributor.authorTseilikman, V. E.en
dc.contributor.authorShatilov, V. A.en
dc.contributor.authorZhukov, M. S.en
dc.contributor.authorBuksha, I. A.en
dc.contributor.authorEpitashvily, A. E.en
dc.contributor.authorLipatov, I. A.en
dc.contributor.authorAristov, M. R.en
dc.contributor.authorKoshelev, A. G.en
dc.contributor.authorKarpenko, M. N.en
dc.contributor.authorTraktirov, D. S.en
dc.contributor.authorMaistrenko, V. A.en
dc.contributor.authorKamel, M.en
dc.contributor.authorBuhler, A. V.en
dc.contributor.authorKovaleva, E. G.en
dc.contributor.authorKalinina, T. S.en
dc.contributor.authorPashkov, A. A.en
dc.contributor.authorKon’kov, V. V.en
dc.contributor.authorNovak, J.en
dc.contributor.authorTseilikman, O. B.en
dc.date.accessioned2024-04-05T16:33:34Z-
dc.date.available2024-04-05T16:33:34Z-
dc.date.issued2023-
dc.identifier.citationTseilikman, V, Shatilov, VA, Zhukov, MS, Buksha, IA, Epitashvily, AE, Lipatov, IA, Aristov, MR, Koshelev, AG, Karpenko, M, Traktirov, DS, Maistrenko, VA, Kamel, M, Buhler, A, Kovaleva, E, Kalinina, TS, Pashkov, AA, Kon’kov, VV, Novak, J & Tseilikman, O 2023, 'Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation', International Journal of Molecular Sciences, Том. 24, № 18, 14343. https://doi.org/10.3390/ijms241814343harvard_pure
dc.identifier.citationTseilikman, V., Shatilov, V. A., Zhukov, M. S., Buksha, I. A., Epitashvily, A. E., Lipatov, I. A., Aristov, M. R., Koshelev, A. G., Karpenko, M., Traktirov, D. S., Maistrenko, V. A., Kamel, M., Buhler, A., Kovaleva, E., Kalinina, T. S., Pashkov, A. A., Kon’kov, V. V., Novak, J., & Tseilikman, O. (2023). Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation. International Journal of Molecular Sciences, 24(18), [14343]. https://doi.org/10.3390/ijms241814343apa_pure
dc.identifier.issn1661-6596-
dc.identifier.otherFinal2
dc.identifier.otherAll Open Access, Gold, Green3
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85172768878&doi=10.3390%2fijms241814343&partnerID=40&md5=03924fe855f7bfbff35744131c94819a1
dc.identifier.otherhttps://www.mdpi.com/1422-0067/24/18/14343/pdf?version=1695207406pdf
dc.identifier.urihttp://elar.urfu.ru/handle/10995/130821-
dc.description.abstractCurrently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD. © 2023 by the authors.en
dc.description.sponsorship23-15-20040; Russian Science Foundation, RSFen
dc.description.sponsorshipThis work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040).en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.relationinfo:eu-repo/grantAgreement/RSF//23-15-20040en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightscc-byother
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/unpaywall
dc.sourceInternational Journal of Molecular Sciences2
dc.sourceInternational Journal of Molecular Sciencesen
dc.subjectANXIETYen
dc.subjectBRAIN-DERIVED NEUROTROPHIC FACTORen
dc.subjectDOPAMINEen
dc.subjectFREEZINGen
dc.subjectMONOAMINES OXIDIZE-Aen
dc.subjectPTSDen
dc.subjectRESVERATROLen
dc.subjectSEROTONINen
dc.subjectBRAIN DERIVED NEUROTROPHIC FACTORen
dc.subjectCATECHOL METHYLTRANSFERASEen
dc.subjectDOPAMINEen
dc.subjectMESSENGER RNAen
dc.subjectMONOAMINEen
dc.subjectRESVERATROLen
dc.subjectSEROTONINen
dc.subjectAMINEen
dc.subjectBRAIN DERIVED NEUROTROPHIC FACTORen
dc.subjectRESVERATROLen
dc.subjectANIMAL BEHAVIORen
dc.subjectANIMAL EXPERIMENTen
dc.subjectANIMAL MODELen
dc.subjectANXIETY DISORDERen
dc.subjectARTICLEen
dc.subjectCHEESEen
dc.subjectCONTROLLED STUDYen
dc.subjectDIET SUPPLEMENTATIONen
dc.subjectDIETARY INTAKEen
dc.subjectELEVATED PLUS MAZE TESTen
dc.subjectENZYME ACTIVITYen
dc.subjectGENE EXPRESSIONen
dc.subjectHIPPOCAMPUSen
dc.subjectMALEen
dc.subjectMONOAMINE METABOLISMen
dc.subjectNONHUMANen
dc.subjectPHENOTYPEen
dc.subjectPOSTTRAUMATIC STRESS DISORDERen
dc.subjectPROTEIN EXPRESSIONen
dc.subjectRATen
dc.subjectSEROTONIN METABOLISMen
dc.subjectANIMALen
dc.subjectDIETARY SUPPLEMENTen
dc.subjectGENETICSen
dc.subjectAMINESen
dc.subjectANIMALSen
dc.subjectBRAIN-DERIVED NEUROTROPHIC FACTORen
dc.subjectCHEESEen
dc.subjectDIETARY SUPPLEMENTSen
dc.subjectRATSen
dc.subjectRESVERATROLen
dc.subjectSTRESS DISORDERS, POST-TRAUMATICen
dc.titleLimited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementationen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/articleen
dc.type|info:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.3390/ijms241814343-
dc.identifier.scopus85172768878-
local.contributor.employeeTseilikman, V.E., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federationen
local.contributor.employeeShatilov, V.A., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeZhukov, M.S., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeBuksha, I.A., Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeEpitashvily, A.E., Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeLipatov, I.A., Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeAristov, M.R., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeKoshelev, A.G., Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.employeeKarpenko, M.N., Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg, 197376, Russian Federationen
local.contributor.employeeTraktirov, D.S., Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg, 197376, Russian Federationen
local.contributor.employeeMaistrenko, V.A., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg, 197376, Russian Federationen
local.contributor.employeeKamel, M., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, Ekaterinburg, 620002, Russian Federationen
local.contributor.employeeBuhler, A.V., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, Ekaterinburg, 620002, Russian Federationen
local.contributor.employeeKovaleva, E.G., Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, Ekaterinburg, 620002, Russian Federationen
local.contributor.employeeKalinina, T.S., Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk, 630090, Russian Federationen
local.contributor.employeePashkov, A.A., Federal Neurosurgical Center, Novosibirsk, 630048, Russian Federation, Department of Data Collection and Processing Systems, Novosibirsk State Technical University, Novosibirsk, 630087, Russian Federationen
local.contributor.employeeKon’kov, V.V., Zelman Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, 630090, Russian Federationen
local.contributor.employeeNovak, J., Department of Biotechnology, University of Rijeka, Rijeka, 51000, Croatia, Center for Artificial Intelligence and Cyber Security, University of Rijeka, Rijeka, 51000, Croatiaen
local.contributor.employeeTseilikman, O.B., Scientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federation, Faculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.issue18-
local.volume24-
dc.identifier.wos001074050800001-
local.contributor.departmentScientific and Educational Center ‘Biomedical Technologies’, School of Medical Biology, South Ural State University, Chelyabinsk, 454080, Russian Federationen
local.contributor.departmentFaculty of Fundamental Medicine, Chelyabinsk State University, Chelyabinsk, 454001, Russian Federationen
local.contributor.departmentPavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg, 197376, Russian Federationen
local.contributor.departmentResearch, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B.N. Yeltsin, Ekaterinburg, 620002, Russian Federationen
local.contributor.departmentInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk, 630090, Russian Federationen
local.contributor.departmentFederal Neurosurgical Center, Novosibirsk, 630048, Russian Federationen
local.contributor.departmentDepartment of Data Collection and Processing Systems, Novosibirsk State Technical University, Novosibirsk, 630087, Russian Federationen
local.contributor.departmentZelman Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, 630090, Russian Federationen
local.contributor.departmentDepartment of Biotechnology, University of Rijeka, Rijeka, 51000, Croatiaen
local.contributor.departmentCenter for Artificial Intelligence and Cyber Security, University of Rijeka, Rijeka, 51000, Croatiaen
local.identifier.pure46011041-
local.description.order14343-
local.identifier.eid2-s2.0-85172768878-
local.fund.rsf23-15-20040-
local.identifier.wosWOS:001074050800001-
local.identifier.pmid37762647-
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