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Поле DC | Значение | Язык |
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dc.contributor.author | Korolkov, I. V. | en |
dc.contributor.author | Zibert, A. V. | en |
dc.contributor.author | Lissovskaya, L. I. | en |
dc.contributor.author | Ludzik, K. | en |
dc.contributor.author | Anisovich, M. | en |
dc.contributor.author | Kozlovskiy, A. L. | en |
dc.contributor.author | Shumskaya, A. E. | en |
dc.contributor.author | Vasilyeva, M. | en |
dc.contributor.author | Shlimas, D. I. | en |
dc.contributor.author | Jażdżewska, M. | en |
dc.contributor.author | Marciniak, B. | en |
dc.contributor.author | Kontek, R. | en |
dc.contributor.author | Chudoba, D. | en |
dc.contributor.author | Zdorovets, M. V. | en |
dc.date.accessioned | 2022-05-12T08:25:27Z | - |
dc.date.available | 2022-05-12T08:25:27Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Boron and Gadolinium Loaded fe3o4 Nanocarriers for Potential Application in Neutron Cancer Therapy / I. V. Korolkov, A. V. Zibert, L. I. Lissovskaya et al. // International Journal of Molecular Sciences. — 2021. — Vol. 22. — Iss. 16. — 8687. | en |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.other | All Open Access, Gold, Green | 3 |
dc.identifier.uri | http://elar.urfu.ru/handle/10995/111882 | - |
dc.description.abstract | In this article, a novel method of simultaneous carborane-and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for fur-ther immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, mor-phology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.description.sponsorship | This study was funded by the Ministry of Education and Science of the Republic of Kazakhstan (grant No. AP08051954 "Synthesis and modification of magnetic nanoparticles for targeted delivery of drugs"), Joint Institute for Nuclear Research-Republic of Kazakhstan cooperation program (Order No. 391, 20 July 2020) and grant №M20MC-024 of The Belarusian Republican Foundation for Fundamental Research. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | MDPI AG | en1 |
dc.publisher | MDPI AG | en |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.source | Int. J. Mol. Sci. | 2 |
dc.source | International Journal of Molecular Sciences | en |
dc.subject | CARBORANE | en |
dc.subject | CYTOTOXICITY | en |
dc.subject | GADOLINIUM | en |
dc.subject | NCT | en |
dc.subject | SUPERPARAMAGNETIC FE3O4 NANOPARTICLES | en |
dc.subject | TARGETED DRUG DELIVERY | en |
dc.subject | BORON | en |
dc.subject | GADOLINIUM | en |
dc.subject | MAGNETITE NANOPARTICLE | en |
dc.subject | BORON NEUTRON CAPTURE THERAPY | en |
dc.subject | CELL PROLIFERATION | en |
dc.subject | CELL SURVIVAL | en |
dc.subject | CHEMISTRY | en |
dc.subject | HUMAN | en |
dc.subject | INFRARED SPECTROSCOPY | en |
dc.subject | MCF-7 CELL LINE | en |
dc.subject | PARTICLE SIZE | en |
dc.subject | PHOTON CORRELATION SPECTROSCOPY | en |
dc.subject | PROCEDURES | en |
dc.subject | RADIATION RESPONSE | en |
dc.subject | SCANNING ELECTRON MICROSCOPY | en |
dc.subject | TUMOR CELL LINE | en |
dc.subject | X RAY DIFFRACTION | en |
dc.subject | BORON | en |
dc.subject | BORON NEUTRON CAPTURE THERAPY | en |
dc.subject | CELL LINE, TUMOR | en |
dc.subject | CELL PROLIFERATION | en |
dc.subject | CELL SURVIVAL | en |
dc.subject | DYNAMIC LIGHT SCATTERING | en |
dc.subject | GADOLINIUM | en |
dc.subject | HUMANS | en |
dc.subject | MAGNETITE NANOPARTICLES | en |
dc.subject | MCF-7 CELLS | en |
dc.subject | MICROSCOPY, ELECTRON, SCANNING | en |
dc.subject | PARTICLE SIZE | en |
dc.subject | PC-3 CELLS | en |
dc.subject | SPECTROSCOPY, FOURIER TRANSFORM INFRARED | en |
dc.subject | X-RAY DIFFRACTION | en |
dc.title | Boron and Gadolinium Loaded fe3o4 Nanocarriers for Potential Application in Neutron Cancer Therapy | en |
dc.type | Article | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.3390/ijms22168687 | - |
dc.identifier.scopus | 85112376680 | - |
local.contributor.employee | Korolkov, I.V., The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty, 050032, Kazakhstan, Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan; Zibert, A.V., The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty, 050032, Kazakhstan, Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan; Lissovskaya, L.I., Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan; Ludzik, K., Department of Physical Chemistry, University of Lodz, Lodz, 90-236, Poland, Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation; Anisovich, M., Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, Minsk, 220012, Belarus; Kozlovskiy, A.L., Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan; Shumskaya, A.E., The Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Minsk, 220072, Belarus; Vasilyeva, M., Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, Minsk, 220012, Belarus; Shlimas, D.I., Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan; Jażdżewska, M., Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation, Faculty of Physics, Adam Mickiewicz University, Poznan, 61-614, Poland; Marciniak, B., Laboratory of Cytogenetics, Faculty of Biology and Enviromental Protection, University of Lodz, Lodz, 90-231, Poland; Kontek, R., Laboratory of Cytogenetics, Faculty of Biology and Enviromental Protection, University of Lodz, Lodz, 90-231, Poland; Chudoba, D., Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation, Faculty of Physics, Adam Mickiewicz University, Poznan, 61-614, Poland; Zdorovets, M.V., The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty, 050032, Kazakhstan, Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan, Department of Intelligent Information Technologies, Ural Federal University, Mira Str. 19, Ekaterinburg, 620002, Russian Federation | en |
local.issue | 16 | - |
local.volume | 22 | - |
dc.identifier.wos | 000690447600001 | - |
local.contributor.department | The Institute of Nuclear Physics, Ibragimov Str. 1, Almaty, 050032, Kazakhstan; Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, Nur-Sultan, 010008, Kazakhstan; Department of Physical Chemistry, University of Lodz, Lodz, 90-236, Poland; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation; Republican Unitary Enterprise, Scientific-Practical Centre of Hygiene, Minsk, 220012, Belarus; The Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Minsk, 220072, Belarus; Faculty of Physics, Adam Mickiewicz University, Poznan, 61-614, Poland; Laboratory of Cytogenetics, Faculty of Biology and Enviromental Protection, University of Lodz, Lodz, 90-231, Poland; Department of Intelligent Information Technologies, Ural Federal University, Mira Str. 19, Ekaterinburg, 620002, Russian Federation | en |
local.identifier.pure | 22979669 | - |
local.description.order | 8687 | - |
local.identifier.eid | 2-s2.0-85112376680 | - |
local.identifier.wos | WOS:000690447600001 | - |
local.identifier.pmid | 34445393 | - |
Располагается в коллекциях: | Научные публикации ученых УрФУ, проиндексированные в SCOPUS и WoS CC |
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